• Advertise
  • Contact Us
  • Write For Us
  • Our Team
Extraction Magazine
No Result
View All Result
  • Botanical Extraction
    • Cannabinoids
    • Psychedelics
    • Nutraceutical
    • Product Refinement
  • Industry News
    • Business
    • Sustainability
    • Safety & Compliance
    • Partners
  • Extraction Technology
    • Equipment
    • Methods
    • Solvents
    • DIY Extraction
    • Analytical Techniques
  • Medical Research
  • Glossary
  • Business Directory
  • Botanical Extraction
    • Cannabinoids
    • Psychedelics
    • Nutraceutical
    • Product Refinement
  • Industry News
    • Business
    • Sustainability
    • Safety & Compliance
    • Partners
  • Extraction Technology
    • Equipment
    • Methods
    • Solvents
    • DIY Extraction
    • Analytical Techniques
  • Medical Research
  • Glossary
  • Business Directory
No Result
View All Result
Extraction Magazine
No Result
View All Result
Home Extraction Technology

Fractionation and Separation Procedures for Increased Purity

Antonio DeRose by Antonio DeRose
July 2, 2022
in Extraction Technology
Fractionation and Separation Procedures for Increased Purity

Making sure your extract has the highest purity is a delicate balance of many variables. However, you can implement certain fractionation and separation procedures to your extraction process to increase the purity of your final extracts. Fractionation and separation processes are used after initial extraction has been completed. Although there are different methods, they all work to isolate your target compound or purify your extract.

 

READ ALSO

Exploring the World of Synthetic vs. Natural Colorants

Pulsed Electric Field Applications for Botanical Extraction

Common Types of Fractionation and Separation Procedures

 

Liquid-Liquid Extraction

You may have heard liquid-liquid extraction referred to as solvent extraction. This is one of the most common separation procedures in use today. It separates compounds depending on their miscibility in two different liquid phases.

Mixer-setters, centrifugal contactors, and continuous countercurrent column methods all rely on this liquid-liquid method. Although this method is proven and widely used, it is somewhat outdated due to the large solvent use and waste.

 

Membrane Filtration

The pharmaceutical and agro-food industries have quickly adopted membrane filtration as a top-choice processing and separation method. By adjusting the membrane pore size, processes like micro-filtration, ultrafiltration, nano-filtration, and reverse osmosis can all be controlled very precisely.

The molecule’s charge and affinity to the membrane filter will also affect outcomes, making membrane filtration more complicated. At the same time, the technology used in these systems is highly automated and intuitive, making it easier to scale. [1]

 

Column Chromatography

Column chromatography is the most popular type of fractionation method for extracts. There are different chromatographic techniques that can separate molecules based on size, charge, polarity and solubility. Two of the newest and most efficient chromatographic techniques are simulated moving bed chromatography (SMB) and sequential multi-column chromatography (SMCC).

One of the biggest advantages of column chromatography is the wide range of application and the high selectivity. Different methods can be used to remove toxins, colors or minerals and It also allows for the accurate recovery of high-quality compounds.[2]

Deciding which fractionation and separation procedure is right for your operation is a matter of your business’s product goals and budget.

 

References:

 

  1. [1] Buonomenna, MG, et al. Organic solvent nanofiltration in pharmaceutical industry. Separation & Purification Reviews. 2014;44(2):157– doi:10.1080/15422119.2014.918884 [Times Cited = 94] [Journal Impact Factor = 9.636]
  2. [2] Ozlem, C. Separation Techniques: Chromatography. North Clin Istanb. 2016; 3(2): 156-160. doi:14744/nci.2016.32757 [Times Cited = 332]Image: Green House Healthy

Related Posts

Synthetic vs. Natural Colorants
Botanical Extraction

Exploring the World of Synthetic vs. Natural Colorants

November 12, 2024
Honeycomb frames in extraction plant at beekeeping factory
Extraction Technology

Pulsed Electric Field Applications for Botanical Extraction

October 29, 2024
How to Use a Gas Chromatograph
Analytical Techniques

How to Use a Gas Chromatograph

October 7, 2024
Combining Extraction Processes
Botanical Extraction

Combination of Extraction Processes

September 26, 2024
Bioreactors
Equipment

Bioreactors Principles, Types, Applications and Limitations

September 23, 2024
THC-O and the Dangers of Non-Natural Cannabinoids
Extraction Technology

THC-O and the Dangers of Non-Natural Cannabinoids: A Call for Caution

September 19, 2024
Next Post
Antioxidants & Extraction

Antioxidants & Extraction

LATEST ARTICLES

Green Extraction Techniques

Green Extraction Techniques and Smart Solvents for Bioactive Recovery

January 10, 2025
Wide angle view at two workers wearing protective suits while inspecting production at modern chemical plant, copy space

Collaborative Approaches in Botanical Extraction: Bridging Science and Industry

January 7, 2025
Areca Catechu

Inside the Betel Nut High: Exploring the Mind-Bending Effects of Areca Catechu

January 1, 2025
The Art of Extraction: Unlocking Nature’s Fragile Secrets

The Art of Extraction: Unlocking Nature’s Fragile Secrets

December 27, 2024

Subscribe Now

Subscribe to our newsletter now to receive quick updates from us



    Background
    About

    Extraction Magazine is the trusted provider of botanical extraction news, ever-changing politics, cool gadgets and technologies, and methods for producing safe, ethical, and compliant formulations.

    Advertisers
    Navigation
    • Botanical Extraction
    • Industry News
    • Extraction Technology
    • Medical Research
    • Glossary
    • Business Directory
    Recent Posts
    • Green Extraction Techniques and Smart Solvents for Bioactive Recovery
    • Collaborative Approaches in Botanical Extraction: Bridging Science and Industry
    • Inside the Betel Nut High: Exploring the Mind-Bending Effects of Areca Catechu
    • The Art of Extraction: Unlocking Nature’s Fragile Secrets
    Subscribe to our Newsletter
    loader

    Sitemap

    © 2025 Extraction Magazine is the trusted provider of botanical extraction news and the leading media in the ever-changing extraction industry.

    No Result
    View All Result
    • Industry News
    • Botanical Extraction
    • Medical Research
    • Medical Research
    • Glossary
    • Our Team
    • Write For Us

    © 2023 Extraction Magazine is the trusted provider of botanical extraction news and the leading media in the ever-changing extraction industry.