• Advertise
  • Contact Us
  • Write For Us
  • Our Team
Extraction Magazine
No Result
View All Result
  • Botanical Extraction
    • Cannabinoids
    • Psychedelics
    • Nutraceutical
    • Product Refinement
  • Industry News
    • Business
    • Sustainability
    • Safety & Compliance
    • Partners
  • Extraction Technology
    • Equipment
    • Methods
    • Solvents
    • DIY Extraction
    • Analytical Techniques
  • Medical Research
  • Glossary
  • Business Directory
  • Botanical Extraction
    • Cannabinoids
    • Psychedelics
    • Nutraceutical
    • Product Refinement
  • Industry News
    • Business
    • Sustainability
    • Safety & Compliance
    • Partners
  • Extraction Technology
    • Equipment
    • Methods
    • Solvents
    • DIY Extraction
    • Analytical Techniques
  • Medical Research
  • Glossary
  • Business Directory
No Result
View All Result
Extraction Magazine
No Result
View All Result
Home Botanical Extraction

Fast Centrifugal Partition Chromatography

Jason Collins by Jason Collins
November 27, 2021
in Botanical Extraction
Fast Centrifugal Partition Chromatography

Fast centrifugal partition chromatography (FCPC) is a system where natural, biological, or synthetic molecules are extracted, separated, and purified. It is a liquid/liquid preparation and industrial chromatography technique. It is regarded to be highly cost-effective and an alternative to purification techniques, such as high-performance liquid chromatography (HPLC) or flash chromatography.

This system functions on the principle of liquid/liquid partition chromatography where two incompatible liquid phases are mixed and separated numerous times. The relative proportions of solute (substances dissolved in solution) passing into each of the two phases are determined by the individual partition factors. One of the solutions provides the stationary phase, while the other solution contains the molecules of interest to be separated. The instrumentation contains multiple cells where the interactions between the two phases occurs, each cell being used in succession.

READ ALSO

Collaborative Approaches in Botanical Extraction: Bridging Science and Industry

Inside the Betel Nut High: Exploring the Mind-Bending Effects of Areca Catechu

Isolating active components from natural products is often complicated by the chemical complexity of plant extracts, however, advances in separation sciences, like the FCPC, have better enabled these separations.

The advantages of FCPC include high purities (up to 99.9%) and quantities, no costs involved for packing material, no losses of samples and 100% recovery, no degradation of fragile/labile molecules, and low solvent use (10-25% less). The natural product industry has used the Safe-by-Design (SbD) method for many years to decrease product toxicity, especially since natural products and their chemistries are a key component in the discovery of new drugs and medication. SbD principles seek to address safety issues during R&D and design phases of novel technologies.

It has been reported that irreversible adsorption on solid support could result in severe losses of valuable materials, chemical reaction of the substrates with solid-phase adsorbents, and isolation of artifacts. For example, solutes binding to alumina and silica supports can limit recoveries to 70-90%. FCPC, by comparison, can result in 90+% recoveries.

FCPC enhances phase separation and can provide a new tool in the field of separation science. FCPC is based on liquid/liquid partitioning and is a scalable alternative to avoid problems associated with solid-phase adsorbents while preserving the chemical integrity of mixtures that have been separated.

Related Posts

Wide angle view at two workers wearing protective suits while inspecting production at modern chemical plant, copy space
Botanical Extraction

Collaborative Approaches in Botanical Extraction: Bridging Science and Industry

January 7, 2025
Areca Catechu
Botanical Extraction

Inside the Betel Nut High: Exploring the Mind-Bending Effects of Areca Catechu

January 1, 2025
The Art of Extraction: Unlocking Nature’s Fragile Secrets
Botanical Extraction

The Art of Extraction: Unlocking Nature’s Fragile Secrets

December 27, 2024
Kava leaves growing naturally
Botanical Extraction

The Chemical Secrets Behind Kava’s Effects

December 27, 2024
The Use of Psychedelics in Trauma Healing
Medical Research

The Use of Psychedelics in Trauma Healing

December 10, 2024
The Art of Extracting Thermolabile Compounds: Dr. Derek Osei Berchie Interview
Botanical Extraction

The Art of Extracting Thermolabile Compounds: Dr. Derek Osei Berchie Interview

December 2, 2024
Next Post
What’s Really in Your Vape?

What’s Really in Your Vape?

LATEST ARTICLES

Green Extraction Techniques

Green Extraction Techniques and Smart Solvents for Bioactive Recovery

January 10, 2025
Wide angle view at two workers wearing protective suits while inspecting production at modern chemical plant, copy space

Collaborative Approaches in Botanical Extraction: Bridging Science and Industry

January 7, 2025
Areca Catechu

Inside the Betel Nut High: Exploring the Mind-Bending Effects of Areca Catechu

January 1, 2025
The Art of Extraction: Unlocking Nature’s Fragile Secrets

The Art of Extraction: Unlocking Nature’s Fragile Secrets

December 27, 2024

Subscribe Now

Subscribe to our newsletter now to receive quick updates from us



    Background
    About

    Extraction Magazine is the trusted provider of botanical extraction news, ever-changing politics, cool gadgets and technologies, and methods for producing safe, ethical, and compliant formulations.

    Advertisers
    Navigation
    • Botanical Extraction
    • Industry News
    • Extraction Technology
    • Medical Research
    • Glossary
    • Business Directory
    Recent Posts
    • Green Extraction Techniques and Smart Solvents for Bioactive Recovery
    • Collaborative Approaches in Botanical Extraction: Bridging Science and Industry
    • Inside the Betel Nut High: Exploring the Mind-Bending Effects of Areca Catechu
    • The Art of Extraction: Unlocking Nature’s Fragile Secrets
    Subscribe to our Newsletter
    loader

    Sitemap

    © 2025 Extraction Magazine is the trusted provider of botanical extraction news and the leading media in the ever-changing extraction industry.

    No Result
    View All Result
    • Industry News
    • Botanical Extraction
    • Medical Research
    • Medical Research
    • Glossary
    • Our Team
    • Write For Us

    © 2023 Extraction Magazine is the trusted provider of botanical extraction news and the leading media in the ever-changing extraction industry.