• Advertise
  • Contact Us
  • Write For Us
  • Our Team
Extraction Magazine
No Result
View All Result
  • Botanical Extraction
    • Cannabinoids
    • Psychedelics
    • Nutraceutical
    • Product Refinement
  • Industry News
    • Business
    • Sustainability
    • Safety & Compliance
    • Partners
  • Extraction Technology
    • Equipment
    • Methods
    • Solvents
    • DIY Extraction
    • Analytical Techniques
  • Medical Research
  • Glossary
  • Business Directory
  • Botanical Extraction
    • Cannabinoids
    • Psychedelics
    • Nutraceutical
    • Product Refinement
  • Industry News
    • Business
    • Sustainability
    • Safety & Compliance
    • Partners
  • Extraction Technology
    • Equipment
    • Methods
    • Solvents
    • DIY Extraction
    • Analytical Techniques
  • Medical Research
  • Glossary
  • Business Directory
No Result
View All Result
Extraction Magazine
No Result
View All Result
Home Industry News

CBD Mitigation of THC-Induced Memory Impairment and Psychosis

Jason S. Lupoi, Ph.D. by Jason S. Lupoi, Ph.D.
January 3, 2020
in Industry News
CBD Mitigation of THC-Induced Memory Impairment and Psychosis

The cannabis renaissance is a global movement. Cannabis is becoming a cherished household word instead of a soft whisper steeped in paranoia. For some, it’s a wonderful botanical relaxant. For others, it builds hope for a sense of wellness not yet achieved. The squashing of taboos isn’t just happening in everyday life. It’s also happening at the university level, which is a beautiful thing, since each stack of papers augments the body of cannabis literature describing what’s possible or not with this complex, intrinsic plant.

Terpenes and cannabinoids are demonstrating their medicinal gifts with stunning regularity. And since terpenes are universal in nature, the volume of science unfolding their power isn’t scant. Although many researchers have been restricted from helping unlock the mysteries of cannabis, tides are turning, times are changing, and scientists are licking hungry chops, eager to delve into the dreamy world of the trichome.

READ ALSO

Green Extraction Techniques and Smart Solvents for Bioactive Recovery

Cannabis Business In South America

A 2018 study evaluated the individual and combined effects of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on memory and psychoses. [1] The attenuation of effects induced by THC when CBD is also present has been previously reported. These findings include increased ability to recognize previously encountered things like events, objects, or people in chronic cannabis users [2]; the lessening of impairment from THC on verbal recall (e.g. remembering a written passage) [3]; and the reduction of symptoms from THC anxiety due to overconsumption. [4]

This study sought to build upon the foundation laid in the scientific literature by considering the effects of CBD and THC when inhaled. The researchers used THC, CBD, and THC + CBD to determine how these combinations would affect memory and incidence of psychosis. Each volunteer in the study received either 8 mg THC, 16 mg CBD, 8 mg THC + 16 mg CBD, or the placebo. The doses of these synthetic cannabinoids were administered using the Volcano Medic Vaporizer. [1]

Participants that received THC or THC+CBD demonstrated increased perceptual distortions and disorganized thinking. Dosing with THC or THC+CBD hindered working (current information in one’s mind) and episodic (information about past events/experiences) memory. Thus, the authors’ hypothesis that CBD would offset the psychotomimetic effects of THC wasn’t proven; CBD did not lessen the effects of THC, despite instances of this phenomenon in the literature.

Interestingly, the authors point to the mixed bag of studies that have demonstrated CBD’s ability or inability to pump the brakes on THC-induced problems like anxiety, paranoia, etc., saying “It may be the case therefore, that CBD is only protective when THC induces a strong psychotic reaction, which might be achieved by using higher doses of THC.” [1]

This study countered another study by the same authors where they found that smoking a cultivar rich in CBD did offset THC-induced memory impairment. [3] Pondering why this might be the case, the authors postulated that terpenes native to the plant might play a role. [1]

CBD used alone improved facial affect recognition (ability to decipher emotion from facial expressions) and lessened THC’s ability to inhibit this process. This protective ability, however, lessened with years of cannabis use. In other words, CBD’s ability to mitigate the effects of THC were thwarted over time.

A task where THC+CBD reigned supreme over CBD, THC, and placebo regarded the participants’ ability to name as many words in 60 seconds that started with a specific letter (you could try this one at home). “One possible tentative explanation is that CBD’s pro-cognitive effects combine with the ability of THC to stimulate novel thinking to result in successful task performance,” the study authors concluded.

Lastly, this study didn’t find any correlation between the common belief and author hypothesis that participants more susceptible to psychosis would be correspondingly prone to pro-psychotic effects from THC. [1]

Each study brings us deeper into our romance with cannabis. It’s a beautiful scene when scientists get gussied up for an evening out with cannabis samples and data and papers, continuously waltzing until the amalgam entwines in a striking display of science, medicine, and open-minded policy that maestros the dance.

References

  1. Morgan, C. et al. “Individual and Combined Effects of Acute Delta-9-Tetrahydrocannabinol and Cannabidiol on Psychotomimetic Symptoms and Memory Function.” Translational Psychiatry, vol. 8, 2018, pp. 181-190. [journal impact factor = 5.182; cited by 11]
  2. Morgan, C. et al. “Sub-Chronic Impact of Cannabinoids in Street Cannabis on Cognition, Psychotic-like Symptoms and Psychological Well-Being.” Psychol. Med., vol. 42, 2012, pp. 391–400. [journal impact factor = 5.641; cited by 101]
  3. Morgan, C. et al. “Impact of Cannabidiol on the Acute Memory and Psychotomimetic Effects of Smoked Cannabis: Naturalistic Study.” Br. J. Psychiatry, vol. 197, 2010, pp. 285–290. [journal impact factor = 7.233; cited by 170]
  4. Englund, A. et al. “Cannabidiol Inhibits THC-Elicited Paranoid Symptoms and Hippocampal-Dependent Memory Impairment.” J. Psychopharmacol., vol. 27, 2013, pp. 19–27. [journal impact factor = 4.738; cited by 195]

Image Credit: NextAvenue.org

Related Posts

Green Extraction Techniques
Sustainability

Green Extraction Techniques and Smart Solvents for Bioactive Recovery

January 10, 2025
A vision for the cannabis business
Business

Cannabis Business In South America

September 16, 2024
Journey of Cannabis in America
Business

From Prohibition to Progress: The Oscillating Journey of Cannabis in America

September 13, 2024
Social Clubs in Spain
Business

Cannabis Social Clubs in Spain vs CoffeeShops in the Netherlands

August 23, 2024
Cannabis Industry Sector
Business

Latest News From The Cannabis Industry Sector

August 16, 2024
Cannabis in Asia
Business

Cannabis in Asia – Overview of Asian Laws

August 9, 2024
Next Post
Common Synthetic Cannabinoids: Uses & Dangers

Common Synthetic Cannabinoids: Uses & Dangers

LATEST ARTICLES

Green Extraction Techniques

Green Extraction Techniques and Smart Solvents for Bioactive Recovery

January 10, 2025
Wide angle view at two workers wearing protective suits while inspecting production at modern chemical plant, copy space

Collaborative Approaches in Botanical Extraction: Bridging Science and Industry

January 7, 2025
Areca Catechu

Inside the Betel Nut High: Exploring the Mind-Bending Effects of Areca Catechu

January 1, 2025
The Art of Extraction: Unlocking Nature’s Fragile Secrets

The Art of Extraction: Unlocking Nature’s Fragile Secrets

December 27, 2024

Subscribe Now

Subscribe to our newsletter now to receive quick updates from us



    Background
    About

    Extraction Magazine is the trusted provider of botanical extraction news, ever-changing politics, cool gadgets and technologies, and methods for producing safe, ethical, and compliant formulations.

    Advertisers
    Navigation
    • Botanical Extraction
    • Industry News
    • Extraction Technology
    • Medical Research
    • Glossary
    • Business Directory
    Recent Posts
    • Green Extraction Techniques and Smart Solvents for Bioactive Recovery
    • Collaborative Approaches in Botanical Extraction: Bridging Science and Industry
    • Inside the Betel Nut High: Exploring the Mind-Bending Effects of Areca Catechu
    • The Art of Extraction: Unlocking Nature’s Fragile Secrets
    Subscribe to our Newsletter
    loader

    Sitemap

    © 2025 Extraction Magazine is the trusted provider of botanical extraction news and the leading media in the ever-changing extraction industry.

    No Result
    View All Result
    • Industry News
    • Botanical Extraction
    • Medical Research
    • Medical Research
    • Glossary
    • Our Team
    • Write For Us

    © 2023 Extraction Magazine is the trusted provider of botanical extraction news and the leading media in the ever-changing extraction industry.